A high-value cosmetic active for measured development of advanced tone-evening, dark-spot and post-blemish mark formulations.
- Targets the human tyrosinase pathway associated with melanin formation [R3–R4].
- Supports formulas designed to improve the look of dark spots and uneven tone.
- Suitable for focused serum, essence, emulsion and spot-care development.
- Available in practical paid small packs for bench work, with commercial quantities by inquiry.
Product Specifications
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Product fact |
Details |
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Product name |
Isobutylamido Thiazolyl Resorcinol Powder / Thiamidol Powder |
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INCI name |
Isobutylamido Thiazolyl Resorcinol |
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CAS number |
1428450-95-6 [R1] |
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Molecular formula |
C13H14N2O3S [R1] |
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Molecular weight |
278.33 g/mol [R1] |
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Ingredient type |
Synthetic resorcinol-derived thiazole cosmetic active |
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Commercial form |
White powder |
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Assay |
≥99% |
Key Benefits
Why Formulators Choose Isobutylamido Thiazolyl Resorcinol
- Human-relevant target: it was identified through screening against human tyrosinase, rather than relying only on mushroom-tyrosinase screening [R3–R4].
- Low-dose development potential: published finished-product studies commonly evaluated 0.2% ITR, making small quantities useful for controlled bench work [R4–R6].
- Evidence breadth: controlled finished-product studies address facial hyperpigmentation and post-inflammatory marks [R4–R6]. New claims must remain cosmetic and formula-specific.
- Clear formula role: a distinct active for carefully controlled tone-evening systems.
Typical Applications
- Targeted dark-spot and uneven-tone facial serums
- Post-blemish mark appearance serums and lightweight gels
- Brightening essences, ampoules and concentrated boosters
- Day or night emulsions designed for a more even-looking complexion
- Professional and laboratory development prototypes for pigment-care concepts
- Sun-protection companion routines; this ingredient is not a UV filter and does not replace sunscreen
Quick Formulation Guide
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Development point |
Buyer guidance |
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Use-level context |
Clinical effective range: 0.1% – 0.2% |
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Phase / solubility |
Not water-soluble — pre-dissolve in glycols (propylene glycol, butylene glycol, ethoxydiglycol) or propanediol before adding to the formulation |
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Order of addition |
Prepare a uniform pre-solution only with a grade-compatible carrier; confirm complete incorporation. |
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pH and heat |
Optimal pH range: 4.0 – 5.5 |
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Compatibility |
Validate color, odor, assay retention, precipitation and packaging interaction in the complete formula. |
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Packaging / storage |
Store raw material at 2 – 8°C, sealed under nitrogen or argon, protected from moisture and light |
Why Source From Us
- Start with samples scale to bulk orders – one supplier from trial to production: Validate with lab samples, then scale to commercial volumes – same quality, same team. No re-qualification, no project delays.
- Formulation support that actually helps – not just a data sheet: We give you hands-on guidance on solubility, temperature, pH, and compatibility. A real formulation partner, not a catalog.
- Reliable supply chain – consistent quality, on-time delivery, batch after batch: Own manufacturing facilities plus long-term partnerships with audited upstream producers ensure batch-to-batch consistency. Full documentation with every shipment. No "sample passes, bulk fails"
- Export-ready documentation – compliance, customs, cleared：Complete technical documentation packages – COA, MSDS, TDS, stability data – batch-specific and regulatory-ready. We handle the paperwork so your compliance and procurement teams can focus on formulation
Recommended Ingredient Pairings
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Recommended ingredient |
Why it pairs well |
Product concept |
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Adds barrier, tone-evenness and skin-conditioning value. |
Daily even-tone serum or emulsion |
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Supports a multi-pathway tone and hydration concept. |
Gentle post-blemish mark serum |
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Adds antioxidant and radiance-focused value. |
Advanced brightening essence |
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Adds soothing and conditioning support to an active-led system. |
Comfort-focused spot-care gel cream |
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Adds hydration and slip to concentrated serum formats. |
Hydrating tone-evening serum |
Scientific Evidence Snapshot
Tyrosinase catalyzes key steps in melanin formation. Isobutylamido Thiazolyl Resorcinol was developed as an inhibitor focused on human tyrosinase [R3–R4]. Controlled finished-formula studies reported improvements in visible facial hyperpigmentation and evaluated post-inflammatory marks [R4–R6].
Research & References
[R1] PubChem: Isobutylamido Thiazolyl Resorcinol — U.S. National Library of Medicine. Identity, formula and molecular weight.
[R2] CosIng: ISOBUTYLAMIDO THIAZOLYL RESORCINOL — European Commission. Cosmetic ingredient naming and functions context.
[R3] Thiamidol® — Hyperpigmentation — Beiersdorf. Developer overview of human-tyrosinase screening and trademark context.
[R4] Effective Tyrosinase Inhibition by Thiamidol Results in Significant Improvement of Mild to Moderate Melasma — Journal of Investigative Dermatology / PubMed. Randomized split-face finished-formula study.
[R5] Thiamidol containing treatment regimens in facial hyperpigmentation — International Journal of Cosmetic Science / PMC. Controlled and real-world finished-product studies.
[R6] Effective reduction of post-inflammatory hyperpigmentation with thiamidol — International Journal of Cosmetic Science / PMC. Post-inflammatory mark appearance studies.
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