Acetyl Tetrapeptide-5 is a specialty cosmetic tetrapeptide supplied here as a 99% white powder for controlled formulation work. It is commonly selected for eye serums, eye creams, gels and other leave-on products designed to improve the look of puffiness, tired-looking under-eyes and loss of smoothness around the eye contour. The powder format gives formulators direct control over active concentration and is well suited to low-dose bench development, pilot batches and scale-up planning.
- Designed for targeted eye-area concepts including puffiness, tired-looking under-eyes and smoother-looking skin.
- Water-soluble peptide suitable for aqueous phases and cool-down incorporation.
- Practical small packs for evaluation, with bulk quantities available by inquiry.
- Formulation and export support available for trial-to-production planning.
Product Specifications
|
Specification |
Product information |
|
INCI name |
Acetyl Tetrapeptide-5 |
|
Commercial form |
White powder |
|
Assay / purity |
≥99% |
|
CAS number |
820959-17-9 [R1] |
|
Molecular formula |
C20H28N8O7 [R1] |
|
Molecular weight |
492.5 g/mol [R1] |
|
Sequence |
Ac-β-Ala-His-Ser-His-OH [R1] |
Key Benefits
Supports a Fresher-Looking Eye Contour: Acetyl Tetrapeptide-5 is commonly chosen for cosmetic formulas aimed at reducing the visible look of under-eye puffiness and helping the eye area appear less tired.Helps Build Smoother, Firmer-Looking Eye-Care Products: The peptide is used in age-support and eye-care concepts where formulators want to support a smoother, more resilient-looking skin surface around the delicate eye area.
Fits Dark-Circle and “Tired-Eye” Cosmetic Concepts: It can be incorporated into eye serums, creams and gels developed around a brighter, more refreshed under-eye appearance, particularly when paired with complementary moisturizing and skin-conditioning actives.
Low-Dose Active for Targeted Premium Formulation: Because Acetyl Tetrapeptide-5 is typically evaluated at low active levels, gram-scale powder packs can support multiple bench batches while giving R&D teams precise control over peptide concentration.
Why Formulators Choose Acetyl Tetrapeptide-5 Powder
The powder format is useful when you want to control the true active level directly instead of dosing a pre-diluted commercial solution. Acetyl Tetrapeptide-5 is water soluble and can be pre-dissolved into a small amount of deionized water before addition to the main batch. Technical supplier literature commonly places the active powder in low-dose eye-care formulation ranges, with cool-down addition and mildly acidic to near-neutral conditions preferred for development. [R2–R4]
Typical Applications
- Eye serums and targeted eye concentrates
- Eye creams and light emulsions
- Cooling eye gels and gel-creams
- Hydrating under-eye products and masks
- Premium leave-on age-support products for delicate facial areas
- R&D prototypes evaluating peptide-based eye-care concepts
Quick Formulation Guide
|
Parameter |
Typical formulation guidance |
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Use level |
approximately 0.01–0.1% [R3–R4] |
|
Solubility / phase |
Water soluble; dissolve in deionized water or add through the aqueous phase / pre-dilution. [R2–R4] |
|
pH |
pH around 5–7. [R3, R7] |
|
Processing temperature |
Add during cool-down; keeping peptide addition below about 45°C. [R3, R7] |
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Compatibility |
Evaluate chelators, transition-metal-containing actives and complex multi-active systems in the final formula rather than assuming universal compatibility. [R7] |
|
Stability testing |
Confirm appearance, pH, preservative performance and peptide retention in your complete formula under real-time and accelerated stability conditions. |
Why Source From Us
- Start with samples scale to bulk orders – one supplier from trial to production: Validate with lab samples, then scale to commercial volumes – same quality, same team. No re-qualification, no project delays.
- Formulation support that actually helps – not just a data sheet: We give you hands-on guidance on solubility, temperature, pH, and compatibility. A real formulation partner, not a catalog.
- Reliable supply chain – consistent quality, on-time delivery, batch after batch: Own manufacturing facilities plus long-term partnerships with audited upstream producers ensure batch-to-batch consistency. Full documentation with every shipment. No "sample passes, bulk fails"
- Export-ready documentation – compliance, customs, cleared：Complete technical documentation packages – COA, MSDS, TDS, stability data – batch-specific and regulatory-ready. We handle the paperwork so your compliance and procurement teams can focus on formulation
Recommended Ingredient Pairings
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Recommended ingredient |
Why it pairs well |
Product concept |
Compatibility note |
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Caffeine |
Supports a familiar refreshed-eye / tired-eye concept and complements lightweight eye serums. |
Cooling eye serum |
Validate total active load, pH and solubility. |
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Adds barrier-support, tone-evenness and broad facial-care value. |
Brightening eye gel-cream |
Keep final pH suitable for both ingredients; run stability testing. |
|
|
Adds hydration and a smoother skin feel around the eye area. |
Hydrating eye serum |
Adjust polymer grade to desired viscosity and avoid over-thickening. |
|
|
Supports soothing, conditioning and moisturization. |
Sensitive-skin eye cream |
Generally formulation-friendly; validate preservation and sensory profile. |
|
|
Adds hydration and environmental-stress support to premium leave-on concepts. |
Premium eye concentrate |
Check cost-in-use, total solids and finished-formula stability. |
Research & References
[R1] PubChem — Acetyl tetrapeptide-5
[R2] Cayman Chemical — Acetyl Tetrapeptide-5 technical information
[R3] Mobel Biotechnology — Acetyl Tetrapeptide-5 TDS
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