Melittin 98% Powder

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✅ Cosmetic Grade Purity
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✅ 1g Sample to Bulk Supply
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A high-purity bee-venom peptide for low-dose sebum-care and advanced peptide formulations. Melittin 98% powder gives professional formulators precise control over active loading in premium serum and emulsion concepts.

98% Melittin powder for professional cosmetic formulation and controlled R&D.
Defined 26-amino-acid Melittin for precise low-dose formulation. [R1–R2]
Supports sebum-balancing cosmetic development; MELITTIN is listed with an anti-sebum function in European cosmetic ingredient

Property	Product Information
Product Name	Melittin / Bee Venom Peptide
Commercial Form	Powder
Purity / Assay	98%
INCI	MELITTIN
CAS Number	20449-79-0 [R2]
Peptide Length	26 amino acids [R1]
Sequence	GIGAVLKVLTTGLPALISWIKRKRQQ-NH2 [R1–R2]
Molecular Formula / MW	C131H229N39O31 / approximately 2846.5 g/mol [R1]
Ingredient Family	Bee-venom peptide / amphipathic bioactive peptide

Key Benefits

Supports sebum-balancing formulas — Useful for lightweight serums and emulsions designed for oily or combination-skin concepts. MELITTIN is listed with an anti-sebum cosmetic function in European ingredient data. [R3]

Adds a distinctive bee-venom peptide active — Melittin gives formulators a differentiated high-value peptide option for premium treatment-style skin-care concepts. It is the principal peptide component of bee venom. [R1]

Supports advanced age-care R&D — Preclinical research gives Melittin a credible development rationale for visible-aging concepts, while human evidence for isolated Melittin remains limited. [R6]

Why Formulators Choose High-Purity Melittin

Formulators choose high-purity Melittin when they want precise control over an ultra-low-dose bee-venom peptide rather than a variable whole-venom mixture. The 98% powder allows clear active calculations, while an aqueous stock solution makes micro-dosing more practical.

Typical Applications

Sebum-balancing facial serums and lightweight emulsions
Advanced bioactive-peptide cosmetic research
Premium bee-venom-inspired skin-care concepts
Low-dose multi-active formulas focused on skin condition and visible aging
Professional R&D prototypes requiring precise Melittin content

How to Formulate With It

Parameter	Typical Formulation Guidance
Use Level	around 0.001–0.01% in the finished formulation. [R10] Recommended Starting Point: begin at 0.001% active (10 ppm) for an experienced professional formulator, then increase only if the finished formula passes irritation/sensitization and stability assessment. [R7,R10]
Solubility / Stock Solution	Water soluble. Use a validated aqueous stock solution rather than attempting to disperse the 98% powder directly into a finished batch. [R10–R11] For micro-dose work, analytical weighing or a supplier-prepared stock is preferred.
Processing	Add during cool-down after high-temperature processing, preferably below 40°C. [R10–R11] Use gentle mixing and avoid unnecessary prolonged heat or repeated freeze-thaw exposure.
pH	Recommended Starting Point: formulate around pH 5.0–7.0, with pH ~5.5–6.0 as a practical first-trial target when the rest of the formula permits. [R11]
Compatibility	Keep the first prototype simple. Pair with mild humectants/barrier actives such as panthenol, betaine, sodium hyaluronate or niacinamide. Avoid strong surfactant systems, proteolytic enzymes, extreme pH and high-irritancy actives until tolerance is established.
Safety Testing	Irritation, sensitization and allergy risk require dedicated finished-product evaluation. Melittin is a known irritant component of bee venom, and bee-venom exposure can trigger immune reactions in susceptible individuals. [R7–R8]
Preservation / Packaging	Aqueous stock solutions and finished products need an appropriate preservation system and contamination-controlled packaging.

First Prototype Example

For a 100 g professional bench prototype, target 0.001% active Melittin (10 ppm). Because this equals only 1 mg of pure peptide, use a validated low-strength stock or analytical micro-weighing. Add during cool-down below 40°C, begin around pH 5.5–6.0, and assess irritation/sensitization plus basic stability before increasing exposure. [R7,R10–R11]

These are development starting conditions; confirm against the selected grade and validate in the complete formula.

Why Source From Us

Start with samples scale to bulk orders – one supplier from trial to production: Validate with lab samples, then scale to commercial volumes – same quality, same team. No re-qualification, no project delays.
Formulation support that actually helps – not just a data sheet: We give you hands-on guidance on solubility, temperature, pH, and compatibility. A real formulation partner, not a catalog.
Reliable supply chain – consistent quality, on-time delivery, batch after batch: Own manufacturing facilities plus long-term partnerships with audited upstream producers ensure batch-to-batch consistency. Full documentation with every shipment. No "sample passes, bulk fails"
Export-ready documentation – compliance, customs, cleared：Complete technical documentation packages – COA, MSDS, TDS, stability data – batch-specific and regulatory-ready. We handle the paperwork so your compliance and procurement teams can focus on formulation

What to Pair It With

Recommended Ingredient	Why It Pairs Well	Product Concept	Compatibility Note
Niacinamide	Adds barrier and sebum-care support through a conventional cosmetic pathway.	Sebum-balancing peptide serum	Validate pH, preservation and irritation potential in the complete formula.
Panthenol	Adds conditioning and comfort to a high-activity peptide concept.	Soothing bee-peptide serum	Comfort positioning does not neutralize Melittin irritation risk; safety testing remains essential.
Betaine	Adds humectancy and mildness.	Minimalist hydration + peptide serum	Check electrolyte load, preservation and peptide stability.
Ectoin	Adds environmental-stress and hydration positioning.	Protective peptide serum	Validate full-formula tolerance and stability.
Sodium Hyaluronate	Adds hydration and skin feel.	Hydrating peptide essence	Manage viscosity and preservation while keeping Melittin dose controlled.
Ceramide NP	Adds barrier-lipid support.	Barrier-support peptide emulsion	Requires suitable emulsion architecture; do not assume reduced sensitization risk.