2'-Fucosyllactose (2'-FL) 95% White Powder

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A high-purity human milk oligosaccharide (HMO) for microbiome-aware, skin-conditioning and tone-care cosmetic development. 2'-Fucosyllactose is a defined trisaccharide made from fucose, galactose and glucose. In cosmetic R&D, it is especially interesting for prebiotic-style skin concepts, urban-stress care and brighter, more even-looking skin.

95% 2'-Fucosyllactose white powder for professional cosmetic formulation.
Freely / highly water soluble, making it simple to build into serums, essences and emulsions. [R3,R4]
Research supports microbiome-aware, tone-care and anti-pollution cosmetic concepts. [R5–R7]

Product Specifications / Key Facts

Property	Product Information
Product Name	2'-Fucosyllactose (2'-FL)
Cosmetic Ingredient Name	FUCOSYLLACTOSE / 2'-FL [R1]
Commercial Form	White powder
Purity / Assay	95%
CAS Number	41263-94-9 [R1,R2,R4]
Molecular Formula	C18H32O15 [R1,R2,R4]
Molecular Weight	Approximately 488.44 g/mol [R4]
Ingredient Type	Human milk oligosaccharide (HMO) / fucosylated trisaccharide
Solubility	Freely / highly soluble in water [R3,R4]

Key Benefits

Supports microbiome-aware skin-care concepts — 2'-FL is one of the best-known HMOs and has been studied as a prebiotic oligosaccharide in skin-microbiome research. [R7]

Helps build brighter, more even-looking skin formulas — Cell and reconstructed-skin research found lower melanin levels after 2'-FL treatment, supporting tone-care product development. [R5]

Fits urban-stress and comfort formulas — Keratinocyte and reconstructed-epidermis research showed protection against particulate-matter-induced stress signals and loss of epidermal integrity. [R6]

Easy to formulate into water-based systems — Its high water solubility makes it practical for serums, essences, lotions and gel-cream formats. [R3,R4]

Adds a differentiated HMO story — 2'-FL gives premium skin-care formulas a recognizable oligosaccharide / HMO platform without requiring a complex oil-soluble delivery system.

Why Formulators Choose It

2'-Fucosyllactose is unusually straightforward for an emerging microbiome active: it is a defined molecule, it dissolves readily in water, and the cosmetic research already spans skin microbiome, pigmentation and pollution-stress models. That makes it useful when a brand wants a modern HMO / prebiotic story without adding a difficult oil-soluble active or a complex ferment mixture.

Best-Fit Product Applications

Microbiome-aware serums and essences
Brightening / even-tone serums
Urban-stress and anti-pollution formulas
Sensitive-skin and barrier-support products
Hydrating gel serums and emulsions
Premium HMO / biotech skin-care concepts

How to Formulate With It

Parameter	Practical Formulation Guidance
Initial Development Window	Start development around 0.5–2.0% of the finished formula. Skin research has used approximately 1–4% in pigmentation models and 1.5–2.5% in microbiome-related in-vitro work; the narrower window is a conservative formulation starting range rather than the merchant specification. [R5,R7]
Recommended Starting Point	Start at 1.0% 2'-FL powder for the first bench prototype. At 95% assay,
Solubility / Phase	Dissolve directly in distilled or deionized water. Add to the water phase or prepare a concentrated aqueous stock before adding to the main batch. [R3,R4]
Addition Stage	Water-phase addition is straightforward. For a first prototype, cool-down addition is convenient when the formula already contains heat-sensitive actives, but 2'-FL is not presented here as a heat-sensitive peptide.
Temperature	For simple development, dissolve at room temperature or with gentle warmth as needed.
pH	Begin around pH 5.0–6.5 for the first cosmetic prototype; optimize based on the complete formula, preservation system and target skin feel.
Compatibility	Pairs well with humectants, niacinamide, ectoin, panthenol and other water-phase actives. Screen very high electrolyte loads or unusual preservative systems in the finished formula.
First Stability Checks	Monitor clarity, color, odor, pH, microbial stability and preservation performance; because 2'-FL is a carbohydrate active, the finished water system still needs a validated preservative strategy.

First Prototype Example

For a 100 g serum, start with 1.05 g of a 95% 2'-Fucosyllactose powder to deliver approximately 1.0 g active 2'-FL. Pre-dissolve it in 8–10 g DI water, add the clear solution to the main water phase or during cool-down, then finish the batch around pH 5.5–6.0. Check clarity, color, odor, pH and preservation performance before testing a higher active level.

Development qualification: these are practical starting conditions based on current skin-research concentrations and established water solubility, not the merchant grade's official use-level specification.

What to Pair It With

Recommended Ingredient	Why It Pairs Well	Product Concept	Compatibility Note
Niacinamide	Adds barrier, tone and sebum-care benefits through a familiar water-phase active.	Microbiome + even-tone serum	Use a skin-compatible pH and validate preservation.
Ectoin	Adds environmental-stress and hydration support.	Urban-defense HMO serum	Easy aqueous pairing; confirm final preservation.
Panthenol	Adds skin-conditioning and comfort.	Sensitive-skin HMO essence	Water-phase friendly; monitor total solids and tack.
Beta-Glucan	Adds soothing and hydration positioning.	Prebiotic-style barrier serum	Manage viscosity and preservation in high-polysaccharide systems.
Sodium Hyaluronate	Adds hydration and skin feel.	Hydrating HMO gel serum	Add in an order that avoids clumping and excessive viscosity.
N-Acetyl Glucosamine	Adds complementary tone and skin-conditioning support.	HMO brightening serum	Good aqueous concept; validate total sugar/solid load and preservation.

What the Research Shows

2'-FL already has several skin-relevant lines of research. A 2022 study showed reduced melanin in melanocytic cells and a 3D human skin model, with activity linked to the AMPK-ULK1 autophagy pathway. [R5] A separate keratinocyte / reconstructed-epidermis study found that 2'-FL reduced particulate-matter-induced inflammatory signaling and helped preserve epidermal thickness and cornified-layer integrity. [R6] A recent review also summarizes in-vitro work in which 2'-FL influenced skin-microbiome-related bacterial growth patterns and places HMOs within the broader prebiotic-oligosaccharide skin-care field. [R7]

Research & References

[R1] Korean Cosmetic Ingredient Dictionary — Fucosyllactose; CAS 41263-94-9; skin-protecting / skin-conditioning; alias 2'-FL.

[R2] PubChem — 2'-Fucosyllactose, CID 170484.

[R3] USP/FCC — 2'-Fucosyllactose; white/off-white powder; freely soluble in water.

[R4] FDA GRAS Notice 852 — identity, molecular formula, molecular weight and high water solubility.

[R5] Human milk oligosaccharide 2'-fucosyllactose promotes melanin degradation via the autophagic AMPK-ULK1 signaling axis. Scientific Reports.

[R6] 2'-Fucosyllactose Attenuates Particulate Matter-Induced Inflammation via Inhibition of Hypoxia-Inducible Factor in Keratinocytes.

[R7] Prebiotic Oligosaccharides in Skin Health: Benefits, Mechanisms, and Cosmetic Applications.

Frequently Asked Questions

What is 2'-Fucosyllactose?

2'-Fucosyllactose, or 2'-FL, is a defined fucosylated trisaccharide and one of the best-known human milk oligosaccharides.

What cosmetic ingredient name is used for 2'-FL?

The Korean cosmetic ingredient dictionary lists Fucosyllactose, with 2'-FL as an alias, and identifies skin-protecting / skin-conditioning functions. [R1]

Is 2'-Fucosyllactose water soluble?

Yes. Authoritative product references describe 2'-FL as freely or highly soluble in water, which makes it well suited to aqueous serums and emulsions. [R3,R4]

What use level should I start with?

For cosmetic bench development, start around 1.0% and evaluate within roughly 0.5–2.0%. This is a practical formulation starting range derived from skin research, not the merchant's official specification. [R5,R7]

Can 2'-FL support a skin-microbiome concept?

Yes, as a microbiome-aware / prebiotic research concept. Current evidence is mainly in vitro, so avoid claiming that a finished product clinically restores or rebalances the microbiome without product-specific data.

Can it be used for brightening formulas?

2'-FL has shown melanin-reduction effects in cell and reconstructed-skin models, supporting tone-care development.

Is this the same as infant-formula 2'-FL?

The molecule is the same defined 2'-FL structure, but commercial grade, specification, documentation and intended use can differ. This SKU is positioned for cosmetic formulation.

Is this product fermentation-derived?

Many commercial 2'-FL ingredients are produced by fermentation, but the manufacturing route of this specific SKU should be confirmed on current supplier documentation before publishing the claim.