Acetyl Hexapeptide-8 Solution (Argireline) 1000 ppm

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A measured peptide solution for formulas targeting smoother-looking skin and visible expression lines. This grade is supplied at 1000 ppm (0.1%) Acetyl Hexapeptide-8, giving formulators a clear active basis for bench work, prototype development and scale-up planning.

1000 ppm (0.1%) Acetyl Hexapeptide-8 active concentration.
Useful in serums, eye-care products, creams, lotions and other leave-on skin-care formats.
Selected for formulas targeting the visible appearance of expression lines and wrinkles.
Practical paid trial sizes for evaluation, with a bulk-supply path for larger projects.

Choose a Trial Size for development work, or Request a Bulk Quote with your target quantity, destination and specification needs.

Product Specifications

Specification	Product information
Product	Acetyl Hexapeptide-8 Solution 1000 ppm
INCI active	Acetyl Hexapeptide-8
Commercial form	Solution
Active concentration	1000 ppm (0.1%) Acetyl Hexapeptide-8
CAS Number (peptide)	616204-22-9 [R1–R2]
Molecular Formula (peptide)	C34H60N14O12S [R2]
Peptide sequence	Ac-Glu-Glu-Met-Gln-Arg-Arg-NH2 [R1–R3]

Key Benefits

Expression-line care: Acetyl Hexapeptide-8 is studied for cosmetic formulas designed to reduce the visible appearance of expression-related facial lines. [R3–R4] learn more about: Argireline vs Matrixyl: Which Anti-Wrinkle Peptide Fits Your Formula？

Smoother-looking skin: Use it in anti-aging concepts where a smoother, more refined surface appearance is a central product goal. Evidence should be translated into appearance-focused cosmetic claims rather than treatment-style claims. [R4]

Targeted facial applications: Well suited to development briefs for forehead lines, eye-area care and other facial zones where repeated expression contributes to visible lines. [R3–R4]

Clear dosing basis: The 1000 ppm solution provides a defined 0.1% peptide-active basis, making it easier to calculate the approximate active ppm contributed by the raw-material solution during development.

Why Formulators Choose Acetyl Hexapeptide-8

Acetyl Hexapeptide-8 is a synthetic hexapeptide derived from a SNAP-25-inspired sequence. Research describes interference with SNARE-complex-dependent exocytosis as part of its proposed mechanism, which is why the ingredient is commonly developed for expression-line cosmetic concepts. [R3]

For formulators, the practical advantage of a 1000 ppm solution is straightforward dosing: adding 1% of this raw-material solution contributes about 10 ppm peptide active; 5% contributes about 50 ppm; and 10% contributes about 100 ppm.
（Related Reading：How to Calculate Acetyl Hexapeptide-8 Use Level）

Typical Applications

Anti-wrinkle and age-support facial serums
Eye serums, eye gels and lightweight eye creams
Forehead and expression-line treatment-style cosmetic formats
Face creams, lotions and emulsions
Gel-serums and water-based leave-on products
Premium multi-peptide skin-care concepts

Quick Formulation Guide

Before read, you may need How to Calculate Acetyl Hexapeptide-8 Use Level

Formulation point	Typical guidance for comparable commercial grades
Raw-material use level	2–10% [R5–R6]
Active delivered from this 1000 ppm solution	2% solution ≈ 20 ppm active; 5% ≈ 50 ppm; 10% ≈ 100 ppm active.
Processing temperature	below 40°C [R6]
pH	range of 3–8. [R6]
Compatibility	Validate in the full formula, especially when using low-pH systems, strong oxidizing conditions or complex multi-active systems.

Quality Documents & Supply Review

Before production approval, confirm the exact grade’s full INCI composition, active basis, carrier, preservation system, pH/specification limits, storage conditions and batch results. Request current documents for the lot or grade you plan to purchase.

Recommended Ingredient Pairings

Recommended Ingredient	Why It Pairs Well	Product Concept	Compatibility Note
Hyaluronic Acid / Sodium Hyaluronate	Adds hydration and surface-plumping support to an expression-line concept.	Hydrating peptide serum or eye gel	Select molecular-weight grade and rheology for the formula; validate preservation and feel.
Niacinamide	Broadens the formula toward barrier-support, tone and texture care.	Daily multi-benefit anti-aging serum	Keep the finished pH suitable for the complete active system.
Panthenol	Adds conditioning and comfort to a peptide-focused formula.	Sensitive-skin-friendly peptide serum	Generally formulation-friendly, but validate the complete preservative system.
Palmitoyl Tripeptide-1 / peptide blend	Builds a multi-peptide age-support concept with complementary cosmetic positioning.	Premium multi-peptide serum	Do not assume automatic synergy; follow the specification of each peptide grade.
Ectoin	Adds hydration/stress-protection positioning to a gentle leave-on concept.	Barrier-support peptide essence	Validate total electrolyte load, pH and preservation in the complete formula.

Frequently Asked Questions

What does 1000 ppm mean?

It means the supplied raw-material solution contains 1000 parts per million Acetyl Hexapeptide-8, equivalent to 0.1% peptide active.

How much active peptide does a 5% addition provide?

A 5% addition of a 1000 ppm solution contributes approximately 50 ppm Acetyl Hexapeptide-8 to the finished formula.

What is a typical use level?

Comparable commercial Argireline-type solutions are commonly published at 2–10% of the finished formula. [R5–R6] Confirm the range against the exact grade you purchase.

When should I add it during manufacturing?

Comparable supplier guidance recommends aqueous-phase or cool-down incorporation, with one technical sheet specifying below 40°C. [R6]

What pH should I use?

One established commercial solution grade publishes pH 3–8 as its formulation range. [R6] Because solution systems differ, confirm the exact pH guidance for your selected 1000 ppm grade.

Can I combine it with other anti-aging actives?

Yes, it can be considered in multi-active skin-care concepts, but compatibility and stability must be validated in the complete formula. Avoid assuming that every peptide solution has identical carrier or preservative chemistry.

Is Acetyl Hexapeptide-8 the same as Botox?

No. Acetyl Hexapeptide-8 is a topical cosmetic peptide ingredient. Although its proposed mechanism is often discussed in relation to SNAP-25/SNARE biology, topical cosmetic use should not be presented as equivalent to botulinum toxin injections. [R3, R9]

What should I compare when buying a 1000 ppm solution?

Compare active concentration, full INCI composition, carrier system, preservative system, pH/specification limits, microbiology, storage requirements and batch documentation—not the “1000 ppm” number alone.

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Acetyl Hexapeptide-8 Solution (Argireline) 1000 ppm