Synthetic Melittin Powder 98%｜Cosmetic Grade Synthetic Bee Venom Peptide

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✅ Cosmetic Grade Purity
✅ COA / TDS / MSDS Available
✅ 1g Sample to Bulk Supply
✅ Global Shipping

Need bulk pricing? For larger quantities, COA/TDS/MSDS, or custom packaging, request a quote.

Shipping information

Orders Ship in 1-4 business days excluding postal holidays. Standard Shipping is USPS Ground Advantage; USPS Priority & UPS for larger orders.

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Product Overview

Phytva supplies synthetic melittin powder for professional cosmetic research, formulation and commercial manufacturing. This product is a laboratory-produced melittin ingredient supplied as a cosmetic raw material—not a finished skincare product and not a bee venom extract.

Product identity: Synthetic Melittin / Synthetic Bee Venom Peptide
Intended use: Professional cosmetic raw material
Available pack sizes: 【500mg / 1g / 5g / 10g / bulk options】
Documentation: Batch COA, TDS and SDS available

Product Specifications / Key Facts

Property	Product Information
Product Name	Synthetic Melittin / Synthetic Bee Venom Peptide
INCI name	MELITTIN
Source	Synthetic
CAS number	20449-79-0
Chemical formula	C₁₃₁H₂₂₉N₃₉O₃₁
Molecular weight	approx. 2,846.5 g/mol
Commercial Form	Powder
Sequence	GIGAVLKVLTTGLPALISWIKRKRQQ-CONH₂
Assay / content	98%
Grade	Cosmetic Grade
Appearance	light-yellow powder
Pack sizes	500mg · 1g · 5g · 10g · bulk on request
Documentation	COA · TDS · SDS available
Storage	Store tightly sealed in a cool, dry place away from heat, light, and moisture. Refrigeration is recommended for extended shelf life. Always use clean, dry utensils when handling the powder.
Lead time	Orders ship in 1–4 business days (excluding postal holidays); bulk lead time confirmed per quotation

Synthetic origin: what it means for buyers

“Synthetic” describes the production origin of this melittin raw material.Phytva can supply this material for buyers who want a laboratory-produced melittin option rather than a whole-bee-venom or bee-venom-extract material.

Synthetic melittin vs bee venom extract

Synthetic melittin refers to a defined, laboratory-produced melittin raw material.
Bee venom extract refers to a material obtained from bee venom and may contain multiple components.
Natural bee venom and synthetic bee venom peptide are not interchangeable product descriptions.

Customers should select the material and specification required for their formulation, rather than assume that one product can replace another.

Intended Applications

This synthetic cosmetic peptide is intended for professional formulation research and commercial product manufacturing, including:

Anti-aging facial serums
Firming and skin-conditioning creams
Eye-area formulations requiring additional stability and safety validation
Professional skincare systems
Peptide concentrate and complex development

Formulation Guide

Recommended use level

0.001–0.01% of the inished formulation is the suggested starting range for laboratory screening. Begin at 0.001% and adjust only after your stability, safety and performance tests support the intended concentration.

This is a formulation-development starting point, not a guaranteed effective or safe dose for every base.

Preparation instructions

Prepare an appropriate stock solution or dispersion under conditions validated for this material.
Confirm the required solvent, pH range, concentration, temperature and mixing method with the TDS.
Add the material during the formulation stage specified in your validated process.
Protect the material from conditions that could affect stability during manufacture and storage.
Complete stability, compatibility, microbial and packaging tests before scale-up.
Assess the final formulation for irritation, sensitisation and target-population safety.

What to Pair It With

Recommended Ingredient	Why It Pairs Well	Product Concept
Niacinamide	Adds familiar barrier and sebum-care support.	Sebum-balancing peptide serum
Panthenol	Adds conditioning and comfort.	Recovery-focused peptide serum
Ectoin	Adds environmental-stress and hydration positioning.	Protective premium peptide serum
Sodium Hyaluronate	Adds hydration and skin feel.	Hydrating peptide essence
Betaine	Adds humectancy and mildness.	Minimalist hydration + peptide serum
Ceramide NP	Adds barrier-lipid support.	Barrier-support peptide emulsion

Quality, Documentation & Supply

What Phytva provides

Batch COA: product identity, assay/content, applicable impurities and microbial status where tested.
TDS: specifications, handling, solubility and formulation-development information.
SDS: safe-handling, exposure-control, storage and disposal guidance.
Batch traceability: lot-specific documentation for qualified purchases.
Supply review: sample, repeat and commercial-quantity availability.

What the Research Shows

Synthetic Melittin can reproduce the defining behavior of the major natural Melittin sequence when the same peptide is made by solid-phase synthesis. A classic synthesis study reported that the synthetic major form produced membrane-channel behavior qualitatively indistinguishable from the major naturally occurring peptide. [R4] For cosmetics, analytical work has measured Melittin in commercial bee-venom creams at low-ppm levels, providing useful context for why pure Melittin is handled as an ultra-low-dose ingredient. [R5] Human wrinkle data exist for a 0.006% whole-bee-venom serum, not isolated Synthetic Melittin, while isolated Melittin skin-aging evidence remains preclinical. [R6–R7] Safety research also shows that Melittin itself can contribute strongly to irritation at higher exposure, so conservative dosing and finished-product tolerance testing remain essential. [R8]

Research & References

[R1] U.S. FDA GSRS — MELITTIN; sequence GIGAVLKVLTTGLPALISWIKRKRQQ; UNII 24VT8NVE75; CAS mapping 20449-79-0.

[R2] PubChem — Melittin; C131H229N39O31; molecular weight 2846.5; current CAS mappings.

[R3] Bachem — Melittin; synthetic source, sequence, CAS 20449-79-0, molecular weight 2846.5; commercial example supplied as TFA salt.

[R4] Solid-phase synthesis of melittin: purification and functional characterization. Biochemistry.

[R5] An LCMS method for the assay of melittin in cosmetic formulations containing bee venom. Anal Bioanal Chem.

[R6] The beneficial effects of honeybee-venom serum on facial wrinkles in humans. Clin Interv Aging.

[R7] Study on the Effect of Bee Venom and Its Main Component Melittin in Delaying Skin Aging in Mice. Int J Mol Sci.

[R8] Antioxidant activity and irritation property of venoms from Apis species.

[R9] Bulk Naturals — Melittin Synthetic Bee Peptide; synthetic cosmetic benchmark for 0.001–0.01%, water solubility and cool-down addition below 40°C.

Frequently Asked Questions

What is synthetic melittin?

Synthetic melittin is a laboratory-produced melittin raw material. It is supplied here as a cosmetic-grade synthetic bee venom peptide, not as a natural bee venom extract.

Where can I buy synthetic melittin peptide?

Phytva offers synthetic melittin powder in 500mg, 1g, 5g and 10g sample packs, subject to availability. Larger commercial quantities can be discussed through a product inquiry.

Is synthetic melittin the same as bee venom extract?

No. Synthetic melittin is a defined laboratory-produced material. Bee venom extract may contain multiple venom components. Review the INCI, assay, specification and documentation before substitution.

Is this purified melittin?

Yes, where the applicable purity or content specification is met. “Purified” should be read alongside the assay definition, impurities and batch COA—not as a standalone guarantee of any particular performance.

Can I use this for cosmetic-grade formulations?

This product is supplied as a cosmetic-grade melittin raw material. The finished product must still meet applicable safety, labelling, claims and regulatory requirements in its target market.

Is synthetic melittin vegan?

This product has a synthetic production origin. Whether it meets a specific vegan standard depends on additional formulation, processing, packaging and certification criteria. Contact us for available supporting information before making a certified-vegan claim.

Is synthetic melittin allergen-free?

No. Having a synthetic origin does not establish that the material is non-allergenic or suitable for every individual. Final formulations should be assessed for irritation and sensitisation, including in populations with relevant allergies.

What is the melittin price?

Sample-pack pricing is shown in the purchase section. Commercial pricing depends on quantity, pack size, destination and documentation requirements.

Can I buy melittin peptide in bulk?

Yes, subject to availability. Submit your required quantity, destination country and intended documentation needs, and we will review bulk supply options.

How should I store synthetic melittin powder?

Store tightly sealed in a cool, dry place away from heat, light, and moisture. Refrigeration is recommended for extended shelf life. Always use clean, dry utensils when handling the powder.

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Product: Synthetic Melittin Powder 98%｜Cosmetic Grade Synthetic Bee Venom Peptide

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Synthetic Melittin Powder 98%｜Cosmetic Grade Synthetic Bee Venom Peptide