3-O-Ethyl Ascorbic Acid 99% Powder | Ethyl Vitamin C

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A water-soluble vitamin C derivative for brightening, antioxidant and even-tone cosmetic formulations, supplied as a 99% powder for bench evaluation, product development and scale-up sourcing.

Supports brighter, more even-looking skin concepts.
Studied for antioxidant and melanogenesis-related activity.
Water-soluble for serums, essences, gels and emulsion water phases.
A more formulation-flexible vitamin C option than highly oxidation-prone L-ascorbic acid.
Available through a small-pack evaluation path with bulk supply by inquiry.

Product Specifications

Specification	Details
INCI Name	3-O-Ethyl Ascorbic Acid
Common Names	Ethyl Ascorbic Acid; Vitamin C Ethyl Ether; VC Ethyl Ether
CAS Number	86404-04-8 [R1]
Molecular Formula	C8H12O6 [R1]
Molecular Weight	204.18 g/mol [R1]
Assay / Purity	≥99%
Ingredient Type	Ethyl ether derivative of L-ascorbic acid

Key Benefits

Brighter, More Even-Looking Tone: 3-O-Ethyl Ascorbic Acid is widely selected for radiance and tone-care formulas. Laboratory and preclinical research has examined tyrosinase inhibition and melanogenesis-related pathways, supporting use in products designed to improve the appearance of dullness and uneven tone. [R2–R4]
Antioxidant Support: The ingredient has demonstrated reducing and free-radical-scavenging activity in laboratory studies, making it useful in antioxidant serums and daily skincare designed around oxidative-stress support. [R2]
Vitamin C Benefits with Greater Formulation Flexibility: Ethyl substitution changes the physicochemical behavior of the ascorbic-acid molecule and improves stability relative to unmodified L-ascorbic acid under many aqueous conditions. That gives formulators more room to build water-based vitamin C products without relying on the very low pH normally associated with pure L-ascorbic acid. [R2–R3]
Strong Fit for Radiance and Age-Support Products: Its vitamin C identity and aqueous-format fit make it useful for radiance, tone-care and age-support products.

Why Formulators Choose 3-O-Ethyl Ascorbic Acid

3-O-Ethyl Ascorbic Acid combines a recognizable vitamin C active with water solubility and a stability profile that can be easier to manage than pure L-ascorbic acid. The 99% powder format supports measured bench work and controlled concentration testing before scale-up.

Typical Applications

Brightening serum: Keeps the vitamin C derivative central to a high-active, water-based concept.
Daily antioxidant serum: Supports a broader antioxidant strategy for routine skincare.
Essence or ampoule: Works well in lightweight, water-rich formats.
Even-tone moisturizer: Can be incorporated through the aqueous phase of an emulsion.
Gel or sheet-mask essence: Water solubility supports clear or low-oil systems.

Quick Formulation Guide

Formulation Item	Typical Guidance
Use Level	A common starting range is 0.5–3% [R5–R7].
Solubility	Water-soluble; pre-dissolve in deionized water or an appropriate hydrophilic phase. [R3,R5,R6,R8]
Addition	Use in the water phase or add as a cool-down solution when the process allows; avoid unnecessary prolonged heat. [R8]
pH	A practical screening zone around pH 5–6. [R2,R6,R8]
Compatibility	Evaluate with the complete active system, electrolytes, chelators, polymers, preservatives and packaging rather than assuming universal compatibility.
Packaging	Limit unnecessary light and oxygen exposure and select packaging.

Quality Documents & Supply

Before production purchasing, review the current batch specification and assay basis against your formula requirements. Confirm any project-specific test methods, impurity limits and packaging needs.

Small packs support bench evaluation. For production quantities, provide quantity, destination and specification needs for quotation.

Recommended Ingredient Pairings

Recommended Ingredient	Why It Pairs Well	Product Concept	Compatibility Note
Niacinamide	Adds barrier-support and complementary tone-care value.	Daily even-tone serum	Validate final pH, color and complete-system stability.
Alpha-Arbutin	Builds a focused multi-active brightening concept.	Targeted tone-care serum	Respect alpha-arbutin pH and temperature requirements.
N-Acetyl Glucosamine	Adds hydration and tone-refining support.	Gentle radiance essence	Check electrolyte load and polymer behavior.
Panthenol	Adds conditioning and comfort to active-led formulas.	Comfort-focused brightening serum	Confirm preservative efficacy in the final water system.
Hyaluronic Acid	Adds hydration and serum texture.	Hydrating vitamin C serum	Pre-hydrate polymer and re-check viscosity after active addition.

Research & References

[R1] PubChem — 3-O-Ethylascorbic acid (CID 150736)

[R2] Liao et al. — Antioxidant Ability and Stability Studies of 3-O-Ethyl Ascorbic Acid

[R3] Iliopoulos et al. — 3-O-Ethyl-L-Ascorbic Acid: Characterisation and Skin Delivery

[R4] Chen et al. — Anti-melanogenic effects of 3-O-Ethyl Ascorbic Acid

[R9] Romita et al. — Allergic Contact Dermatitis to 3-O-Ethyl-L-Ascorbic Acid

Frequently Asked Questions

Is 3-O-Ethyl Ascorbic Acid the same as L-ascorbic acid?

No. It is an ethyl ether derivative of L-ascorbic acid with different stability and physicochemical behavior.

What is a typical use level?

A common commercial starting range is approximately 0.5–3% . Validate the final level in the selected grade and complete formula.

Is it water-soluble?

Yes. Multiple technical and scientific sources describe 3-O-Ethyl Ascorbic Acid as water-soluble.

What pH should I use?

A mildly acidic formula is a sensible starting point; pH 5–6 is a practical screening zone. Validate final stability, clarity and preservation.

Can I use it with niacinamide?

Yes, they can be evaluated together. Confirm compatibility in the complete formula because concentration, pH, solvents, preservation and other actives can change results.

Is it more stable than pure vitamin C?

Published work supports greater stability than unmodified L-ascorbic acid under many conditions, but heat, light, oxygen, metals and pH still matter.

Can I apply the powder directly to skin?

No. This is a cosmetic raw material intended for controlled formulation, not direct undiluted application.

What should I request before a bulk order?

Request the current specification and relevant product documents, then confirm assay basis, test methods, packaging, quantity and destination.

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Product: 3-O-Ethyl Ascorbic Acid 99% Powder | Ethyl Vitamin C

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3-O-Ethyl Ascorbic Acid 99% Powder | Ethyl Vitamin C