Carnosine 98% White Powder

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A high-purity anti-glycation dipeptide for advanced healthy-aging and antioxidant cosmetic formulations. Carnosine (β-alanyl-L-histidine) is a naturally occurring dipeptide studied for its ability to interact with reactive carbonyl species, reduce glycation-related chemistry and support antioxidant defense. This ≥98% white powder gives formulators a concentrated, water-compatible active for serums, essences, creams and multi-active skin-aging systems.

≥98% Carnosine powder for professional cosmetic formulation.
Strong anti-glycation / carbonyl-scavenging scientific positioning. [R3–R4]
Recognized as a skin-conditioning cosmetic ingredient in Europe. [R2]
Paid evaluation quantities and bulk inquiry support development from bench testing to scale-up.

Product Specifications / Key Facts

Property	Product Information
Product Name	Carnosine / L-Carnosine
Commercial Form	White powder
Purity / Assay	≥98%
INCI	CARNOSINE [R2]
CAS Number	305-84-0 [R1]
Molecular Formula / MW	C9H14N4O3 / 226.23 g/mol [R1]
Chemical Identity	β-Alanyl-L-histidine
Ingredient Family	Dipeptide / anti-glycation / antioxidant cosmetic active

Key Benefits

Supports anti-glycation skin-care concepts — A systematic review found that most included studies supported Carnosine's ability to inhibit advanced glycation end-product formation, protein carbonylation or glycoxidation. [R3]

Helps protect against glycation-related protein damage — Human-skin explant research found that a Carnosine-containing topical cream significantly reduced AGE markers after methylglyoxal-induced glycation. [R4]

Adds antioxidant and carbonyl-scavenging value — Carnosine is widely studied for antioxidant and reactive-carbonyl-scavenging activity, creating a useful technical story for environmental-stress and healthy-aging formulations. [R3,R7]

Fits firmness and elasticity-focused formulas — A 56-day open-label clinical study of a multi-active facial cream containing Carnosine reported improvements in firmness, elasticity, hydration and facial contour. [R5] These are formula-level results, not isolated-Carnosine proof.

Why Formulators Choose Carnosine

Carnosine offers a distinctive anti-aging story because it targets glycation-related chemistry rather than relying only on conventional radical scavenging. Glycation contributes to protein cross-linking and carbonyl stress, making Carnosine particularly relevant to formulas focused on firmness, resilience and long-term visible skin quality. Its small dipeptide structure and water compatibility also make it easier to incorporate into aqueous and emulsion systems than many lipophilic antioxidant actives.

Typical Applications

Anti-glycation serums and essences
Healthy-aging facial creams and emulsions
Firmness and elasticity-focused treatments
Environmental-stress antioxidant products
Barrier-support / hydration systems
Multi-active longevity-inspired cosmetic concepts

Quick Formulation Guide

Parameter	Typical Formulation Guidance
Solubility / Phase	Carnosine is a water-compatible dipeptide and is commonly formulated through the aqueous phase or a water-based stock solution. Confirm complete dissolution at the intended concentration.
Processing	Prefer moderate processing and avoid unnecessary prolonged high heat. If practical, add during a cooler phase after high-temperature emulsification steps.
Compatibility	Carnosine can be combined conceptually with humectants, barrier actives and antioxidants, but high-reactivity oxidizers, strongly acidic/alkaline systems and complex metal-ion environments should be stability-tested.
Preservation	Aqueous Carnosine formulas require an appropriate preservation strategy; the peptide itself is not a preservative.
Packaging	Use packaging appropriate for aqueous antioxidant systems and validate color, odor, pH and assay over shelf life.

Quality Documents & Supply

Before scale-up, review the current COA/TDS for assay method and tolerance, appearance, moisture or loss on drying, pH of a defined solution if specified, residual solvents or process impurities, heavy metals, storage and packaging. If customers require vegan/synthetic origin or fermentation-route claims, verify the actual manufacturing route instead of inferring it from the molecule's natural occurrence.

Recommended Ingredient Pairings

Recommended Ingredient	Why It Pairs Well	Product Concept
Niacinamide	Adds barrier, tone and healthy-aging support through a different pathway.	Anti-glycation + barrier serum
Ectoin	Adds environmental-stress and hydration positioning.	Urban-stress healthy-aging serum
Ergothioneine	Adds complementary antioxidant / cellular-stress positioning.	Advanced longevity-inspired antioxidant serum
Acetyl Zingerone	Adds modern photoaging and reactive-species antioxidant support.	Anti-glycation + photoaging serum
Sodium Hyaluronate	Adds hydration and skin-feel support.	Hydrating anti-glycation essence
Panthenol	Adds conditioning and comfort.	Soothing healthy-aging serum

Scientific Evidence Snapshot

Carnosine has a broad anti-glycation evidence base, but the type of evidence matters. A systematic review covering 36 studies found that nearly all reported anti-glycation activity, while noting that most studies were in vitro or animal and only two involved humans. [R3] In human skin explants, a topical Carnosine cream reduced AGE markers after methylglyoxal challenge. [R4] Clinical cosmetic evidence is more formulation-dependent: an open-label multi-active face cream containing Carnosine improved firmness, elasticity, hydration and facial contour over 56 days. [R5] More recent delivery research has explored supramolecular Carnosine systems for improved skin interaction and anti-glycation/photoaging performance. [R6]

Research & References

[R1] PubChem — Carnosine (CID 439224): CAS 305-84-0; C9H14N4O3; MW 226.23.

[R2] COSMILE Europe — CARNOSINE, cosmetic function: skin conditioning.

[R3] Carnosine and advanced glycation end products: a systematic review. Amino Acids.

[R4] Novel Facial Cream Containing Carnosine Inhibits Formation of Advanced Glycation End-Products in Human Skin.

[R5] Redefining face contour with a novel anti-aging cosmetic product: open-label prospective clinical study.

[R6] Topical Transdermal Administration of Supramolecular Self-Assembled Carnosine for Anti-Melanin and Anti-Aging.

Frequently Asked Questions

What is Carnosine?

Carnosine is the dipeptide β-alanyl-L-histidine, naturally present in human and animal tissues and widely studied for antioxidant and anti-glycation activity.

What is the CAS number of Carnosine?

Carnosine is CAS 305-84-0 with molecular formula C9H14N4O3 and molecular weight 226.23 g/mol. [R1]

Is Carnosine water soluble?

Carnosine is commonly handled as a water-compatible active and can be incorporated through the aqueous phase or a water-based stock solution.

What does anti-glycation mean in skincare?

Glycation is a non-enzymatic reaction that can form advanced glycation end products and protein cross-links. Carnosine is studied for its ability to reduce carbonyl/glycation chemistry. [R3–R4]

Is there human evidence for topical Carnosine?

There is human-skin explant evidence and clinical data from multi-active cosmetic formulas containing Carnosine. [R4–R5]

What use level should I use?

Follow the current grade TDS and finished-product safety/stability assessment. Public supplier ranges should not be treated as universal for every ≥98% powder.

What should I review before bulk purchase?

Review assay method/tolerance, appearance, moisture, impurity/heavy-metal controls, storage/packaging and manufacturing origin if vegan/synthetic-source claims are important.