A next-generation chromanol antioxidant for advanced photoaging and environmental-stress cosmetic formulations. Dimethylmethoxy Chromanol is a bioinspired antioxidant structurally related to the chromanol family associated with tocopherols. This 98% powder provides a concentrated active for serums, creams, emulsions and sophisticated antioxidant systems where reactive-species control, visible photoaging support and formulation stability are key development goals.
- 98% Dimethylmethoxy Chromanol powder for professional cosmetic formulation.
- Direct research demonstrates efficient singlet-oxygen quenching in solution and ex-vivo skin. [R3]
- Human combination-formula studies support photoaging, tone, elasticity and barrier-related product concepts. [R4–R5]
Product Specifications / Key Facts
|
Property |
Product Information |
|
Product Name |
Dimethylmethoxy Chromanol |
|
Commercial Form |
Powder |
|
Purity / Assay |
98% |
|
INCI |
DIMETHYLMETHOXY CHROMANOL |
|
CAS Number |
83923-51-7 [R1–R2] |
|
Molecular Formula / MW |
C12H16O3 / 208.25 g/mol [R1] |
|
UNII |
XBH432G01F [R1] |
|
Ingredient Family |
Chromanol derivative / next-generation antioxidant |
Key Benefits
Supports broad antioxidant defense — Dimethylmethoxy Chromanol is designed as a chromanol antioxidant and has strong direct evidence for quenching singlet oxygen, a reactive oxygen species associated with photooxidative skin stress. [R3]
Fits photoaging-focused skin-care development — A 3-month clinical study found that adding Dimethylmethoxy Chromanol-loaded antioxidant particles plus Spirulina to an SPF 30 sunscreen improved pigmentation, dermal collagen-degradation-related measurements and net elasticity compared with sunscreen alone. [R4]
Supports visible tone, barrier and firmness concepts — A 4-week serum study combining DMC with turmeric root extract reported improvements in skin lightness, redness, TEWL, gloss and firmness. [R5]
Adds a differentiated tocopherol-inspired antioxidant story — The molecule is widely described as a gamma-tocopherol-inspired chromanol, giving brands a premium antioxidant positioning distinct from conventional vitamin E.
Why Formulators Choose Dimethylmethoxy Chromanol
This ingredient combines a compact small-molecule identity with strong singlet-oxygen research and a broad reactive-species defense story. It is especially relevant when a formulation needs an antioxidant active that can complement, rather than simply duplicate, conventional tocopherol or vitamin C strategies.
Typical Applications
- Premium antioxidant serums and emulsions
- Photoaging and environmental-stress facial care
- Day creams and antioxidant-support sunscreen-adjacent products
- Firmness, radiance and uneven-tone cosmetic systems
- Multi-antioxidant formulations with tocopherols, vitamin C derivatives or ferulic acid
- Advanced oil-serum and anhydrous antioxidant systems
Quick Formulation Guide
|
Parameter |
Typical Formulation Guidance |
|
Solubility / Phase |
supports pre-dissolution in alcohol or compatible organic solvents such as ethoxydiglycol / dimethyl isosorbide, or incorporation into a suitable oil phase. [R8] |
|
Processing |
Maintain complete dissolution and avoid unnecessary prolonged heat or light. [R7] |
|
Compatibility |
Build the antioxidant system deliberately. Tocopherol, vitamin C derivatives and other antioxidants may create complementary coverage |
|
Photoprotection |
Dimethylmethoxy Chromanol can support photoaging-defense concepts but is not a UV filter and does not replace sunscreen or SPF/UVA testing. |
|
Packaging |
Light-limiting and low-air-exposure packaging. |
Quality Documents & Supply
Before scale-up, review the current COA/TDS for assay method and tolerance, appearance, identity, melting range where applicable, moisture/loss on drying, impurities, storage and packaging.
Product Specifications / Key Facts
|
Property |
Product Information |
|
Product Name |
Dimethylmethoxy Chromanol |
|
Commercial Form |
Powder |
|
Purity / Assay |
98% |
|
INCI |
DIMETHYLMETHOXY CHROMANOL |
|
CAS Number |
83923-51-7 [R1–R2] |
|
Molecular Formula / MW |
C12H16O3 / 208.25 g/mol [R1] |
|
UNII |
XBH432G01F [R1] |
|
Ingredient Family |
Chromanol derivative / next-generation antioxidant |
Key Benefits
Supports broad antioxidant defense — Dimethylmethoxy Chromanol is designed as a chromanol antioxidant and has strong direct evidence for quenching singlet oxygen, a reactive oxygen species associated with photooxidative skin stress. [R3]
Fits photoaging-focused skin-care development — A 3-month clinical study found that adding Dimethylmethoxy Chromanol-loaded antioxidant particles plus Spirulina to an SPF 30 sunscreen improved pigmentation, dermal collagen-degradation-related measurements and net elasticity compared with sunscreen alone. [R4]
Supports visible tone, barrier and firmness concepts — A 4-week serum study combining DMC with turmeric root extract reported improvements in skin lightness, redness, TEWL, gloss and firmness. [R5] Because the study used a combination serum without a placebo arm, these results are formula-level evidence rather than proof of DMC alone.
Adds a differentiated tocopherol-inspired antioxidant story — The molecule is widely described as a gamma-tocopherol-inspired chromanol, giving brands a premium antioxidant positioning distinct from conventional vitamin E.
Why Formulators Choose Dimethylmethoxy Chromanol
This ingredient combines a compact small-molecule identity with strong singlet-oxygen research and a broad reactive-species defense story. It is especially relevant when a formulation needs an antioxidant active that can complement, rather than simply duplicate, conventional tocopherol or vitamin C strategies. The practical formulation challenge is solubility: current technical sources place Dimethylmethoxy Chromanol in alcohol, organic-solvent or oil-phase systems rather than simple water-phase processing.
Typical Applications
- Premium antioxidant serums and emulsions
- Photoaging and environmental-stress facial care
- Day creams and antioxidant-support sunscreen-adjacent products
- Firmness, radiance and uneven-tone cosmetic systems
- Multi-antioxidant formulations with tocopherols, vitamin C derivatives or ferulic acid
- Advanced oil-serum and anhydrous antioxidant systems
Quick Formulation Guide
|
Parameter |
Typical Formulation Guidance |
|
Solubility / Phase |
supports pre-dissolution in alcohol or compatible organic solvents such as ethoxydiglycol / dimethyl isosorbide, or incorporation into a suitable oil phase. [R8] |
|
Processing |
Maintain complete dissolution and avoid unnecessary prolonged heat or light. [R7] |
|
Compatibility |
Build the antioxidant system deliberately. Tocopherol, vitamin C derivatives and other antioxidants may create complementary coverage. |
|
Photoprotection |
Dimethylmethoxy Chromanol can support photoaging-defense concepts but is not a UV filter and does not replace sunscreen or SPF/UVA testing. |
|
Packaging |
Light-limiting and low-air-exposure packaging. |
Quality Documents & Supply
Before scale-up, review the current COA/TDS for assay method and tolerance, appearance, identity, melting range where applicable, moisture/loss on drying, impurities, storage and packaging.
Recommended Ingredient Pairings
|
Recommended Ingredient |
Why It Pairs Well |
Product Concept |
|
Adds a conventional lipid-phase antioxidant pathway to the chromanol-based system. |
Dual-chromanol antioxidant cream |
|
|
Adds complementary modern antioxidant and photoaging research. |
Next-gen antioxidant serum |
|
|
Adds phenolic antioxidant-network potential. |
Environmental-defense serum |
|
|
Adds a lipophilic vitamin C pathway. |
Premium oil-soluble antioxidant system |
|
|
Adds hydration and environmental-stress positioning. |
Urban-defense serum |
|
|
Provides an elegant oil-phase base for lipophilic antioxidant systems. |
Antioxidant facial oil / emulsion |
Scientific Evidence Snapshot
Dimethylmethoxy Chromanol has strong mechanistic antioxidant evidence and useful, though mainly combination-based, human data. Direct photochemical research showed rapid singlet-oxygen quenching in solution and a clear reduction of singlet-oxygen lifetime and emission in ex-vivo porcine skin. [R3] In a 44-subject, three-month sunscreen study, a formula containing Spirulina plus DMC-loaded solid lipid nanoparticles improved pigmentation, collagen-degradation-related skin measurements and net elasticity versus sunscreen alone. [R4] A 2023 study also found that a 1:1 DMC/turmeric-root-extract combination enhanced antioxidant-enzyme responses in UVB-stressed keratinocytes; the related 24-subject serum study reported improvements in tone, redness, TEWL, gloss and firmness after four weeks. [R5] These results support advanced antioxidant/photoaging positioning.
Research & References
[R1] U.S. FDA GSRS / UNII — Dimethylmethoxy Chromanol, CAS 83923-51-7, C12H16O3, UNII XBH432G01F.
[R6] Lubrizol — Sun Care Brochure, Lipochroman molecule, INCI Dimethylmethoxy Chromanol.
[R7] Lubrizol — SPF 30 Glamourous Sun Elixir formulation using 0.05% Dimethylmethoxy Chromanol.
Frequently Asked Questions
You may also like
-
DDBD Diacetate 99 Percent Powder
Regular price From $39.90 USDRegular price$0.00 USDSale price From $39.90 USD -
Acetyl Octapeptide-3 (SNAP-8) Cosmetic Grade Peptide
Regular price From $39.90 USDRegular price$0.00 USDSale price From $39.90 USD -
GHK-Cu Blue Powder 99% | Copper Tripeptide-1
Regular price From $14.90 USDRegular price$0.00 USDSale price From $14.90 USD -
PDRN / Sodium DNA Powder 99% (Polydeoxyribonucleotide)
Regular price From $14.90 USDRegular price$0.00 USDSale price From $14.90 USD -
Matrixyl 3000 Palmitoyl Tripeptide-1 + Palmitoyl Tetrapeptide-7 Peptide Blend — 200 ppm Premix Liquid
Regular price From $19.90 USDRegular price$0.00 USDSale price From $19.90 USD -
Synthetic Melittin Powder 98%｜Cosmetic Grade Synthetic Bee Venom Peptide
Regular price From $49.00 USDRegular price$0.00 USDSale price From $49.00 USD -
Diglucosyl Gallic Acid 98% Powder
Regular price From $29.90 USDRegular price$0.00 USDSale price From $29.90 USD -
Tetrahydrocurcumin 98% Powder
Regular price From $16.90 USDRegular price$0.00 USDSale price From $16.90 USD
Request a Quote
Tell us your required quantity, destination country, and any documentation needs. We usually reply within 1 business day.