A ready-to-formulate 10% HPR concentrate for advanced anti-aging and next-generation retinoid skincare. Hydroxypinacolone Retinoate (HPR) is a modern retinoid ester used in cosmetic formulations for visible age-support, texture and tone. This grade contains 10% HPR in Dimethyl Isosorbide (DMI), giving formulators a convenient liquid route for dosing a highly active retinoid into serums, emulsions, creams and oil-soluble systems.
- 10% Hydroxypinacolone Retinoate active in Dimethyl Isosorbide.
- Designed for premium fine-line, wrinkle, texture and photoaging-focused cosmetic concepts.
- Liquid concentrate simplifies active-level calculations compared with handling pure HPR powder.
- HPR has shown comparatively strong stability among retinoids studied in commercial cosmetic products. [R5]
Product Specifications / Key Facts
|
Property |
Product Information |
|
Product Name |
Hydroxypinacolone Retinoate 10% Solution |
|
Common Abbreviation |
HPR |
|
Commercial Form |
Oil-soluble solution / dispersion |
|
HPR Active Content |
10% |
|
Carrier / Solvent |
Dimethyl Isosorbide (DMI) |
|
INCI Components |
Hydroxypinacolone Retinoate, Dimethyl Isosorbide |
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HPR CAS / Formula / MW |
893412-73-2 / C26H38O3 / 398.6 g/mol [R1] |
|
DMI CAS / Formula / MW |
5306-85-4 / C8H14O4 / 174.19 g/mol [R2] |
|
Ingredient Family |
Vitamin A retinoid derivative / retinoic-acid ester |
Supports visible wrinkle and fine-line improvement — HPR-containing finished formulations have been evaluated in human anti-aging studies, supporting evidence-aware wrinkle and photoaging product concepts. [R3–R4]
Helps refine skin texture and smoothness — Clinical combination-product research reports improvements in visible texture and smoothness, making HPR relevant to premium skin-renewal positioning. [R3–R4]
Supports firmness and elasticity-focused formulas — HPR-containing retinoid systems have shown improvements in elasticity-related clinical measures in human studies. [R3–R4]
Useful in tone and radiance concepts — Recent HPR-containing cosmetic studies include improvements in photodamage, hyperpigmentation or tone-related appearance measures. [R3]
Modern retinoid option with favorable stability evidence — A comparative cosmetic stability study found HPR to be the most stable of the retinoids examined. [R5]
Why Formulators Choose HPR 10% in DMI
The 10% concentrate format gives formulators two practical advantages: a clearly defined HPR loading and a liquid carrier that simplifies dosing into compatible systems. Dimethyl Isosorbide is the confirmed solvent for this grade, so the raw material can be treated as a two-component solution rather than a pure HPR powder. HPR also has a distinct stability profile: comparative testing in commercial cosmetics found it more stable than the other retinoids evaluated, but light and elevated temperature still accelerated retinoid degradation overall. [R5] That makes formulation design and packaging just as important as the starting active.
Typical Applications
- Night serums and intensive age-support treatments
- Fine-line and wrinkle-focused creams
- Oil serums and anhydrous retinoid systems
- Emulsions and gel-creams with an appropriate oil/solvent phase
- Premium photoaging, texture and tone-care concepts
- Multi-retinoid systems developed with controlled stability testing
Quick Formulation Guide
|
Parameter |
Typical Formulation Guidance |
|
Active Calculation |
1% of the concentrate contributes approximately 0.10% HPR active; 0.5% contributes 0.05%, and 3% contributes 0.30%. |
|
Use Level |
Current comparable 10% HPR/DMI commercial guidance includes raw-material use up to about 3% in finished formulas. [R7] Select the level by target HPR active |
|
Phase / Solubility |
The commercial grade is a DMI solution intended for oil-soluble / compatible mixed-phase systems. Incorporate into a suitable oil, solvent or emulsion architecture rather than treating it as a simple water-phase active. |
|
Processing |
Minimize prolonged heat and strong-light exposure during processing. Retinoids remain formulation-sensitive even when HPR shows comparatively favorable stability. [R5] |
|
Compatibility |
Evaluate strong oxidizers/reducers, extreme pH, high-reactivity actives and packaging interactions through finished-formula stability testing. |
|
Packaging |
Opaque, UV-protective or otherwise light-limiting packaging; minimize unnecessary headspace and heat exposure where the product architecture permits. |
Recommended Ingredient Pairings
|
Recommended Ingredient |
Why It Pairs Well |
Product Concept |
|
Adds barrier-lipid support to a retinoid-focused product. |
HPR + ceramide night cream |
|
|
Adds barrier, hydration and tone-care value. |
HPR + niacinamide serum / cream |
|
|
Supports conditioning and comfort around retinoid use. |
Comfort-focused HPR serum |
|
|
Adds hydration and slip. |
Hydrating HPR serum |
|
|
Adds oil-phase antioxidant support. |
Protected HPR oil phase |
|
|
Provides an elegant emollient oil phase for premium retinoid formulas. |
HPR facial oil / emulsion |
Scientific Evidence Snapshot
The human evidence base for HPR is growing, A 16-week study of a cosmetic serum containing HPR and peptides reported significant improvements across multiple visible facial-aging parameters. [R3] A separate study combining HPR with retinyl propionate reported improvements in wrinkles, smoothness, TEWL and elasticity after eight weeks. [R4] These studies support HPR as a credible next-generation retinoid for age-support development. Stability research is more directly ingredient-relevant: HPR showed the strongest stability among the retinoids examined in a six-month cosmetic-product study, while light and heat remained important degradation factors. [R5]
Research & References
[R1] PubChem — Hydroxypinacolone Retinoate: CAS 893412-73-2; C26H38O3; MW 398.6.
[R2] PubChem — Dimethyl Isosorbide: CAS 5306-85-4; C8H14O4; MW 174.19.
Frequently Asked Questions
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